TY - JOUR AU - Yan, Minhong PY - 2011/08/08 TI - Therapeutic promise and challenges of targeting DLL4/NOTCH1 JF - Vascular Cell; Vol 3 No 1 (2011): VascularCellDO - 10.1186/2045-824X-3-17 KW - N2 - Abstract DLL4-mediated NOTCH1 signaling represents an essential pathway for vascular development and has emerged as an attractive target for angiogenesis-based cancer therapies. However, newly reported toxicity findings raise safety concerns of chronic pathway blockade. Lessons learned from the development of γ-secretase inhibitors (GSIs) might offer insights into how to safely harness this important signaling pathway. UR - https://vascularcell.com/index.php/vc/article/view/10.1186-2045-824X-3-17