%A Newman, Andrew C %A Hughes, Christopher C W %D 2012 %T Macrophages and angiogenesis: a role for Wnt signaling %K %X Abstract Macrophages regulate many developmental and pathological processes in both embryonic and adult tissues, and recent studies have shown a significant role in angiogenesis. Similarly, Wnt signaling is fundamental to tissue morphogenesis and also has a role in vascular development. In this review, we summarize recent advances in the field of macrophage-regulated angiogenesis, with a focus on the role of macrophage-derived Wnt ligands. We review data that provide both direct and indirect evidence for macrophage-derived Wnt regulation of physiologic and pathologic angiogenesis. Finally, we propose that Wnt signaling plays a central role in differentiation of tumor associated and wound infiltrating macrophages to a proangiogenic phenotype. %U https://vascularcell.com/index.php/vc/article/view/10.1186-2045-824X-4-13 %J Vascular Cell %0 Journal Article %R 10.1186/2045-824X-4-13 %P 13%V 4 %N 1 %@ 2045-824X %8 2012-08-31