It's hard to keep all things angiogenic in one JAR!
Vascular Cell. 2011;
Received: 22 December 2010 | Accepted: 18 January 2011 | Published: 18 January 2011
Vascular Cell ISSN: 2045-824X
It's hard to keep all things angiogenic in one JAR!
"All things angiogenic" could mean many things to the many different types of researchers in the field. This diversity of thought is clearly reflected by the articles presented since the launch of the
As a result of this diversity of thoughts, of research topics, and of researchers, we came to realize that all things angiogenic/vascular could not be kept in one single JAR! The publication platform, developed as a venue for angiogenic researchers, was found to be relevant and of interest to researchers studying the many facets of human vasculature, not limited to those who study the construction of new vessels.
Vascular biology including angiogenesis research is one of the fastest expanding fields in biomedical research. Almost all developmental processes are coupled to vascular growth, remodeling and functions. Structural or functional defects of the vascular network are tightly linked to the onset, development and progression of various human diseases including those most common and lethal disorders such as cancer, cardiovascular disease, obesity, metabolic disorders and chronic inflammation. While major scientific journals such as
Specific examples of this overlapping/novel technology include recent developments in tissue engineering, where human fibroblasts extracted from skin biopsies were formed into a cohesive sheet and then used as a matrix to engineer new blood vessels using Teflon-coated stainless steel support tubes and attachment of an internal membrane and peripheral adventitial coating using patient-only cells. These have been shown to be antithrombogenic and stable for extended periods of time and could provide a valuable alternative to the use of synthetic or xenogeneic vessels for transplant in patients with advanced cardiovascular disease . Nanotechnology will have an increasing role in development of scaffolding, targeting of molecules and imaging platforms over the next few years. Optimizing the process of vascularization/angiogenesis is important in the treatment of ischaemic disease, and Sinha Roy et al  demonstrated this recently by encapsulating NK1 (a splice variant of hepatocyte growth factor) in biodegradable nanoparticles composed of D, L-lactic acid-co-glycolic acid copolymer, and demonstrated both temporal release and enhanced vascularization in a matrigel-implanted zebrafish model of vasculogenesis.
In other vascular diseases, including neurodegenerative diseases such as Alzheimer's, understanding the mechanisms that cause vascular abnormalities and impair cerebral blood flow could provide some of the answers to the importance of ischaemia (possibly initiated following ischaemic or lacunar stroke) in formation of vascular amyloidosis and dense-core plaques . Newly developed and currently developing vascular imaging techniques may help us to identify earlier, patients at risk of progressing to pre-senile dementia, and also could be useful in detecting vascular-associated lesional changes after stroke, and in primary (e.g. glioblastoma) or metastasized brain tumours. In this respect, Kienast et al  used multiphoton laser scanning microscopy to image single steps of metastasis formation in a mouse brain in real-time. Translated to humans, understanding the individual fate of tumour cells, their movement through microvessels and perivascular growth could help us modify existing therapeutic strategies. These are only a few examples of the range of topics appropriate to be included in
- Novel insights into the differential functions of Notch ligands in vascular formation. J Angiogenesis Res. 2010;1:8-.
- Differentiation of the brain vasculature: The answer came blowing in the Wnt. J Angiogenesis Res. 2010;2:1-.
- Endothelial progenitor cells: what use for the cardiologist?. J Angiogenesis Res. 2010;2:26-.
- Micro computed tomography for vascular exploration. J Angiogenesis Res. 2010;2:7-.
- Long-term progestin contraceptives (LTPOC) induce aberrant angiogenesis, oxidative stress and apoptosis in the guinea pig uterus: A model for abnormal uterine bleeding in humans. J Angiogenesis Res. 2010;2:8-.
- A role for Egfl7 during endothelial organization in the embryoid body model system. J Angiogenesis Res. 2010;2:4-.
- Physiologic upper limits of pore size of different blood capillary types and another perspective on the dual pore theory of microvessel permeability. J Angiogenesis Res. 2010;2:14-.
- Human tissue-engineered blood vessels for adult arterial revascularization. Nat Med. 2006;12:361-5.
- Coupling growth-factor engineering with nanotechnology for therapeutic angiogenesis. Proc Natl Acad Sci USA. 2010;107:13608-13.
- Primary Cerebral Blood Flow Deficiency and Alzheimer's Disease: Shadows and Lights. J Alzheimers Dis. 2010.
- Real-time imaging reveals the single steps of brain metastasis formation. Nat Med. 2010;16:116-22.
- . Therapeutic angiogenesis for vascular disease: Molecular mechanisms and targeted clinical approaches for the treatment of angiogenic disease. 2011.