Dll4-Notch signaling as a therapeutic target in tumor angiogenesis

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Frank Kuhnert Jessica R Kirshner Gavin Thurston



Tumor angiogenesis is an important target for cancer therapy, with most current therapies designed to block the VEGF signaling pathway. However, clinical resistance to anti-VEGF therapy highlights the need for targeting additional tumor angiogenesis signaling pathways. The endothelial Notch ligand Dll4 (delta-like 4) has recently emerged as a critical regulator of tumor angiogenesis and thus as a promising new therapeutic anti-angiogenesis target. Blockade of Dll4-Notch signaling in tumors results in excessive, non-productive angiogenesis with resultant inhibitory effects on tumor growth, even in some tumors that are resistant to anti-VEGF therapies. As Dll4 inhibitors are entering clinical cancer trials, this review aims to provide current perspectives on the function of the Dll4-Notch signaling axis during tumor angiogenesis and as a target for anti-angiogenic cancer therapy.

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KUHNERT, Frank; KIRSHNER, Jessica R; THURSTON, Gavin. Dll4-Notch signaling as a therapeutic target in tumor angiogenesis. Vascular Cell, [S.l.], v. 3, n. 1, p. 20, sep. 2011. ISSN 2045-824X. Available at: <https://vascularcell.com/index.php/vc/article/view/10.1186-2045-824X-3-20>. Date accessed: 23 oct. 2021. doi: http://dx.doi.org/10.1186/2045-824X-3-20.