Eicosapentaenoic acid inhibits endothelial cell migration in vitro

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Laura Tonutti Luca Manzi Maria T Tacconi Gianfranco Bazzoni



As n-3 Polyunsaturated Fatty Acids exert a beneficial action on the cardiovascular system, it is important to investigate their effects on endothelial cell responses that (like migration) contribute to repairing vascular lesions.


To this purpose, using functional and morphological in vitroassays, we have examined the effect of n-3 Polyunsaturated Fatty Acids on the migration of endothelial cells.


We report here that incubation of endothelial cells with n-3 Polyunsaturated Fatty Acids impaired cell migration into a wound, triggered peripheral distribution of focal adhesions and caused partial disassembly of actin filaments. We also found that eicosapentaenoic acid and docosahexaenoic acid exerted similar effects on the focal adhesions, but that eicosapentaenoic acid was sufficient for inhibiting cell migration.


Given the importance of endothelial cell migration in the repair of vascular injuries, these in vitrofindings call for in vivoevaluation of vascular repair in response to different dietary ratios of eicosapentaenoic to docosahexaenoic acid.

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How to Cite
TONUTTI, Laura et al. Eicosapentaenoic acid inhibits endothelial cell migration in vitro. Vascular Cell, [S.l.], v. 2, n. 1, p. 12, july 2010. ISSN 2045-824X. Available at: <https://vascularcell.com/index.php/vc/article/view/10.1186-2040-2384-2-12>. Date accessed: 18 june 2024. doi: http://dx.doi.org/10.1186/2040-2384-2-12.
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