Notch regulates the angiogenic response via induction of VEGFR-1

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Yasuhiro Funahashi Carrie J Shawber Marina Vorontchikhina Anshula Sharma Hasina H Outtz Jan Kitajewski



Notch is a critical regulator of angiogenesis and arterial specification. We show that ectopic expression of activated Notch1 induces endothelial morphogenesis in human umbilical vein endothelial cells (HUVEC) in a VEGFR-1-dependent manner. Notch1-mediated upregulation of VEGFR-1 in HUVEC increased their responsiveness to the VEGFR-1 specific ligand, Placental Growth Factor (PlGF). In mice and human endothelial cells, inhibition of Notch signaling resulted in decreased VEGFR-1 expression during VEGF-A-induced neovascularization. In summary, we show that Notch1 plays a role in endothelial cells by regulating VEGFR-1, a function that may be important for physiological and pathological angiogenesis.

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FUNAHASHI, Yasuhiro et al. Notch regulates the angiogenic response via induction of VEGFR-1. Vascular Cell, [S.l.], v. 2, n. 1, p. 3, jan. 2010. ISSN 2045-824X. Available at: <>. Date accessed: 15 june 2024. doi:
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