Therapeutic promise and challenges of targeting DLL4/NOTCH1

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Minhong Yan


DLL4-mediated NOTCH1 signaling represents an essential pathway for vascular development and has emerged as an attractive target for angiogenesis-based cancer therapies. However, newly reported toxicity findings raise safety concerns of chronic pathway blockade. Lessons learned from the development of γ-secretase inhibitors (GSIs) might offer insights into how to safely harness this important signaling pathway.

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How to Cite
YAN, Minhong. Therapeutic promise and challenges of targeting DLL4/NOTCH1. Vascular Cell, [S.l.], v. 3, n. 1, p. 17, aug. 2011. ISSN 2045-824X. Available at: <>. Date accessed: 23 oct. 2021. doi: