Macrophages and angiogenesis in rheumatic diseases

Main Article Content

Nicola Maruotti Tiziana Annese Francesco Paolo Cantatore Domenico Ribatti

Abstract

Angiogenesis plays a key role in several rheumatic diseases, including rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, systemic sclerosis, systemic lupus erythematosus, and vasculitides. An imbalance between angiogenic inducers and inhibitors seems to be a critical factor in pathogenesis of these diseases. Macrophages promote angiogenesis during rheumatoid arthritis. In addition, macrophages can produce a variety of pro-angiogenic factors that have been associated with the angiogenic response occurring during other rheumatic diseases. Lastly, macrophages could be a target in the treatment of rheumatoid arthritis and other rheumatic diseases. Nevertheless, further studies are needed to better elucidate the exact role of macrophage in angiogenesis in these diseases.

Article Details

How to Cite
MARUOTTI, Nicola et al. Macrophages and angiogenesis in rheumatic diseases. Vascular Cell, [S.l.], v. 5, n. 1, p. 11, june 2013. ISSN 2045-824X. Available at: <https://vascularcell.com/index.php/vc/article/view/10.1186-2045-824X-5-11>. Date accessed: 11 aug. 2022. doi: http://dx.doi.org/10.1186/2045-824X-5-11.
Section
Review