Vascular endothelial growth factor-B expression in postischemic rat brain

Main Article Content

Lin Xie Xiaoou Mao Kunlin Jin David A Greenberg

Abstract

Background

Vascular endothelial growth factor-B (VEGF-B) protects against experimental stroke, but the effect of stroke on VEGF-B expression is uncertain.

Methods

We examined VEGF-B expression by immunohistochemistry in the ischemic border zone 1–7 days after middle cerebral artery occlusion in rats.

Results

VEGF-B immunoreactivity in the border zone was increased after middle cerebral artery occlusion and was associated with neurons and macrophages/microglia, but not astrocytes or endothelial cells.

Conclusions

These findings provide additional evidence for a role of VEGF-B in the endogenous response to cerebral ischemia.

Article Details

How to Cite
XIE, Lin et al. Vascular endothelial growth factor-B expression in postischemic rat brain. Vascular Cell, [S.l.], v. 5, n. 1, p. 8, apr. 2013. ISSN 2045-824X. Available at: <https://vascularcell.com/index.php/vc/article/view/10.1186-2045-824X-5-8>. Date accessed: 11 aug. 2022. doi: http://dx.doi.org/10.1186/2045-824X-5-8.
Section
Original Research