Macrophages and angiogenesis: a role for Wnt signaling

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Andrew C Newman Christopher C W Hughes


Macrophages regulate many developmental and pathological processes in both embryonic and adult tissues, and recent studies have shown a significant role in angiogenesis. Similarly, Wnt signaling is fundamental to tissue morphogenesis and also has a role in vascular development. In this review, we summarize recent advances in the field of macrophage-regulated angiogenesis, with a focus on the role of macrophage-derived Wnt ligands. We review data that provide both direct and indirect evidence for macrophage-derived Wnt regulation of physiologic and pathologic angiogenesis. Finally, we propose that Wnt signaling plays a central role in differentiation of tumor associated and wound infiltrating macrophages to a proangiogenic phenotype.

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NEWMAN, Andrew C; HUGHES, Christopher C W. Macrophages and angiogenesis: a role for Wnt signaling. Vascular Cell, [S.l.], v. 4, n. 1, p. 13, aug. 2012. ISSN 2045-824X. Available at: <>. Date accessed: 20 jan. 2022. doi: